Gotrium Continuously advancing on the path of lensless chip digital microscopy technology!

Tech 2023-05-21 00:39:50 Source: Network

Author IntroductionLu Dahua, Deputy General Manager of Nanjing Jiuchuan Science and Technology Co., Ltd

Author Introduction

Lu Dahua, Deputy General Manager of Nanjing Jiuchuan Science and Technology Co., Ltd., biomedical engineering, member of the Experimental Medicine (Transformation) Expert Committee of the National Health Industry Enterprise Management Association, has been engaged in the medical device industry for more than 30 years.

By the time this year's CACLP was held, Nanjing Province Science and Technology Co., Ltd. (referred to as "Jiuchuan Technology" in Chinese) had entered its fifth year of research and development in life science instruments and medical devices for lensless chip digital microscopy. Its core technology - VPS chip digital microscopy technology is based on China's independently developed vertical charge transfer imaging device (VPS), from initial principle innovation and method establishment (see previous reports: CACLP2021 | Exploring Medical Digital Black Technology - Full Field High Resolution Digital Microchips and CACLP2022 | Thinking and Risk Response for Medical Device Innovation) to feasibility exploration in various sub fields, We have obtained a large amount of experimental data. Therefore, in response to clinical testing needs and pain points, we have proposed a series of medical device solutions and simultaneously promoted the registration of medical devices.

Since the day when Jiuchuan Technology started developing and transforming VPS chip digital microscopy technology, it has been focusing on clinical testing needs and pain points. It does not make copies of existing equipment or replace existing equipment, relying on digital chip microscopy image detection technology to generalize high-precision equipment, simplify complex systems, and try to complement existing equipment, Create medical devices that are popular in the market for effectively solving clinical problems.

After digitizing medical images and pathological section microscopic images, remote consultation can be achieved, transferring the clinical diagnosis and treatment capabilities of medical experts from large hospitals to grassroots hospitals; The digitization here refers to converting optical microscopic images into electrical signal microarrays based on pixels through image sensing chips, digitizing the electrical signals of each pixel to obtain microarray images of different gray scales. This image is transmitted, shared, and saved as a digital slide on the Internet, facilitating the provision of disease diagnosis and treatment basis for doctors in different environments, and facilitating learning and communication between doctors. However, devices that rely on microscopes to obtain microscopic images cannot do without laboratories, which limits the coverage of remote diagnosis and treatment, and the terminal requirements are still high. The role of digitizing microscopic images under lenses is limited to image transmission. VPS lensless microscopy, as it does not use lenses for microscopic image acquisition and digitization, can be made into portable devices that use VPS lensless microscopy technology to obtain microscopic images for diagnosis and evaluation. This has great conversion value for applications such as field operations, sampling in special environments, unmanned monitoring, POCT diagnosis, and home self inspection.

Microscopic examination is the gold standard for IVD detection, but its widespread use is hindered by issues such as low detection rate, low detection efficiency, and strong experience dependence. People have to find other physical and chemical methods to replace microscopic examination. After digitizing microscopic images, artificial intelligence assisted diagnosis technology has greatly made up for these shortcomings. However, obtaining full field microscopic images requires precise scanning devices, which are large in size and expensive. The VPS chip digital microscopy technology can provide a large field of view high-resolution microscopy image without splicing in a single photo, providing an image foundation for rapid artificial intelligence assisted diagnosis, making digital morphological detection simple and feasible, and greatly reducing costs. The automated body fluid analysis all-in-one machine that Jiuchuan Technology is about to launch is a miniaturized automatic detection equipment suitable for urine, vaginal discharge and other body fluid samples, combined with morphology and dry chemistry detection, designed for grassroots hospitals. It provides precision medical treatment for grassroots hospitals in a low-cost, multifunctional, automated, and high-performance manner.

The distortionless grayscale microarray provided by VPS chip digital microscopy technology can serve as an array spectrophotometer to record, measure, and analyze the physical and chemical information of the measured substance at the three-dimensional space nanometer level, providing quantitative diagnostic technology for pathological diagnosis based on cell lifecycle information and the discovery of abnormal cells. Compared to microscopes that only provide single-layer physical and chemical information of the measured substance, VPS lensless microscopy technology obtains the integral value of the physical and chemical information of the measured substance on the longitudinal axis of each pixel unit, and then forms a large-scale high-resolution photometric microarray. Therefore, VPS lensless microscopy can obtain richer and more comprehensive information compared to microscopy, providing more accurate quantitative diagnosis.

By utilizing VPS chip digital microscopy technology to continuously capture living cells in culture for a long time, the cell laboratory no longer requires laboratory personnel to be on duty, ensuring that the growth, reproduction, apoptosis, and interaction processes of all cells are recorded without omission. All records are made into videos, making it convenient for researchers to observe. Personalized analysis software can be developed for all records according to researchers' needs, The ordinary carbon dioxide incubator has become a dynamic observation system for living cells. The dynamic observation system for living cell culture of Jiuchuan Technology utilizes the existing carbon dioxide incubator in your laboratory, which is equipped with self-developed on-chip cultivation observation equipment and software. It will free the hands and time of life science researchers, improve observation ability, discover small probability events, accelerate the research process of life science, and ensure the quality of cell therapy. At present, the system has been widely used in life science laboratories, pharmaceutical research laboratories, and cell factories.

VPS chip digital microscopy technology can provide medical devices with the ability to output high-resolution microscopic images with a wide field of view. Medical devices based on VPS chip digital microscopy technology no longer require the use of microscopes and scanning devices. The device structure is simple, maintenance is convenient, and it is easier to combine with technologies such as sample automation preprocessing, high-throughput detection, and artificial intelligence assisted diagnosis, creating various types of medical devices that meet clinical needs and improve detection levels Medical devices suitable for various application scenarios. Such as miniaturized morphology and chemical/immune detection integrated machines, high-throughput automated bacterial/tumor cell morphology detection equipment, POCT digital immune analyzer, POCT cell/microbial/particulate matter unmanned online monitoring instrument, etc.

In the process of converting VPS chip digital microscopy technology into medical devices, too many life science laboratories, cell factories, clinical laboratories, and pathology departments have provided us with requirements, samples, and pre experimental sites; Too many medical device raw material manufacturers and manufacturers have provided us with valuable experience and suggestions, and we would like to express our gratitude together! VPS chip digital microscopy technology can be transformed into various types of life science instruments and medical devices, involving many interdisciplinary disciplines and relying on the application needs and experience of many experts. On the occasion of the upcoming opening of CACLP, we sincerely invite industry colleagues to visit the booth of Jiuchuan Technology (booth number: A2-1305) to explore and explore the transformation and application of VPS chip digital microscopy technology, using our common wisdom and experience, Building a Better IVD Tomorrow!

About VPS Technology

In 2009, members of the founding team of Weipaishi proposed a new concept of vertical charge transfer imaging device (VPS), which is entirely based on standard CMOS technology. It solves the problem of full well charge limited by pixel structure. Compared with traditional CCD or CMOS imaging technology, VPS technology uses a single transistor to achieve all functions of CIS unit pixels (one diode and 3-4 transistors), Pushing the pixel size from "micrometer level" to "nanometer level", we have achieved a pixel size of 0.5 micrometers and a pixel size of 600 million, leading the world in terms of pixel size. We are the world's smallest and largest lensless micro image sensing chip.

About Jiuchuan Technology

Nanjing Jiuchuan Science and Technology Co., Ltd. is an innovative company focused on applying China's independently created and world leading VPS ultra large scale lensless image sensing chips to fields such as life science research, clinical diagnosis, public health prevention, food and drug safety supervision, and environmental protection.

Nanjing Jiuchuan Science and Technology Co., Ltd. has pioneered the concept of Giga level "chip digital microscope", solving the contradiction between large field of view and high-resolution images. It has launched various modular digital microscope imaging instruments and solutions based on VPS chips, such as cell/particle morphology full field counter, live cell culture dynamic monitoring system, and high-throughput automation for clinical testing and pathological diagnosis Portable bedside cell morphology analysis system. Nanjing Jiuchuan Science and Technology Co., Ltd. gathers talents from various fields such as medicine, industry, technology, and trade, working together with experts in the fields of biology and medicine and peers in medical device manufacturing. Starting from meeting major needs and solving user pain points, we open up cross-border innovation barriers and continue to create VPS biological and medical application products and solutions.

About Weipaishi

Nanjing Weipaishi Semiconductor Technology Co., Ltd. focuses on the research and application design of the next generation of ultra large scale pixel image sensing chip products, with its independently innovative vertical charge transfer imaging device (VPS) as its core. It is committed to providing ultra large scale imaging chips and solutions with future oriented and high-quality imaging performance for medical, life sciences, commercial satellites, and other fields. It is a leader in the solution of billion pixel imaging chips. The founding team of the company comes from well-known universities such as Nanjing University, Sony, Infineon, and overseas chip companies. The research and development team has a master's and doctoral ratio of over 90%, and has rich experience in the semiconductor industry. The team has completed the research and development of the first chip, with a pixel size of 600 million and a pixel size of 0.5 micrometers. It is the smallest and largest reported imaging chip in terms of pixel size, mainly targeting fields such as healthcare and life sciences, and has applied for more than 40 core intellectual property rights.

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