21CC Cancer Intelligence (Issue 47): Reindeer Bio/Xinda Bio BCMA Targeted CAR-T Therapy Approved for Market Launch; The latest phase 3 test results of AstraZeneca HIMALAYA are positive
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21CC(cancercare)2121CC//BCMACAR-T630NMPABBCMACAR-TMM3BCMACAR-TCT103AIBI326BCMACAR-TTCARscFvCD8a4-1BBCD3NMPAFDA/20232FDA/NMPA20226628NMPArepotrectinibROS1Rafael AmadoROS15CDEROS16281ALKNSCLCWX-0593ALK/ROS1ALKALKROS1WX-0593ALKROS1NSCLC180mgIIALK1469.390412056IRCORR67
21CC(cancercare)2121CC
/
/BCMACAR-T
630NMPABBCMACAR-TMM3BCMACAR-T
CT103AIBI326BCMACAR-TTCARscFvCD8a4-1BBCD3NMPAFDA/20232FDA/
NMPA20226
628NMPArepotrectinibROS1
Rafael AmadoROS1
5CDEROS1
6281ALKNSCLC
WX-0593ALK/ROS1ALKALKROS1WX-0593ALKROS1NSCLC180mg
IIALK1469.390412056
IRCORR67.8%DCR96.6%ORR61.6%DCR94.5%DoR13.1PFS/TTP14.41881.9%
NSCLC
627RETNMPARETNSCLC
ARROWI/IIRETNSCLCRET
627HR2HER2
1CDK4/6
CDK4/6Ibrance20152FDAHRHER220162HRHER2Palbociclib20187PalbociclibHRHER2
EvaluatePharma202288.7Insight57.95%
CAR-T
626NMPACDE12Br/r LBCL
2017Gilead SciencesKite PharmaYescartaAxicabtagene CiloleucelCD19CAR-TCAR-TTT
//
LumakrasNSCLC IIIK
627IIICodeBreaK 202sotorasibLumakrasKIVIIIB/CNSCLC
750PD-L1KRAS p.G12CNSCLCPFS20239203011
SotorasibCarmot TherapeuticsKRAC G12CIIICodeBreaK 20020215FDAKRAS G12CNSCLCCodeBreaK 200PD-1/PD-L1NSCLCsotorasibKKPD-L1NSCLC
HIMALAYA3
630AstraZenecaHIMALAYA34ImjudotremelimumabImfinzidurvalumabOS
82657%
ImfinziPD-L1PD-L1PD-1CD80FDAImjudoCTLA-4CTLA-4T
ImfinziImjudoSTRIDESingle Tremelimumab Regular Interval DurvalumabImjudo300 mgImfinzi1500 mgImfinzi3HIMALAYA10
III
630IIIGEMSTONE-3042023ESMO (ESMO GI 2023)
GEMSTONE-304IIIFP+BICRPFSOSPFSBICRORRDoR
2022107PFSOSGEMSTONE-304BICRPFSOS
6291167.HKJCA-AACRJCA-AACR Precision Cancer Medicine International ConferenceKRAS G12CJAB-21822KRAS G12C
33.3%11/3390.9%30/33mPFS6.962.8%27/4393%40/432023523TARE1-2
553%KRAS G12CKRAS G12C
RDCI
627(RDC) TLX250-CDx (89Zr-TLX250)(ccRCC)I
TLX250-CDxII10/(PET/CT)
TLX250-CDx ccRCC RDC IX (CA9)CA9 ccRCC ccRCCTLX250-CDx FDA
ADC
626PD-1MSLN ADC RC88 c-METADCRC108
I/IIaRC88RC108
PD-1 PD-1
RC88MSLNADC201811RC88MSLN
RC108c-METADC202011c-MetRC108c-MET
629(IARC)(JECFA)714
5 WHO
6 29 ICBA
21APP
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Tag: Bio 21CC Cancer Intelligence Issue Reindeer Xinda BCMA Targeted
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